Refractory Angina and Peripheral Artery Disease

People with angina complain of frequent chest pains that feel heavy or tight. It usually occurs with any kind of exertion including emotional stress and is caused by insufficient blood supply to the heart. Refractory angina is when the angina could not be controlled or relieved by conventional medications or procedures such as angioplasty, coronary stenting and/or heart bypass operation. Patients with diabetes are more likely to develop refractory angina. Patients with refractory angina suffer from daily attacks of angina that limits their activities and quality of life. Furthermore, as with any patient with coronary disease, there is a 10-30% risk of heart attack, stroke or death in the next ten years.

Peripheral Artery Disease (PAD) is a condition where long blood vessels supply to arms and legs are blocked as a result of smoking, diabetes, and high cholesterol. As the blood supply becomes interrupted, patients normally complain that their calves are painful or cramp during walking.

Current treatments, including angioplasty and bypass are ineffective because these patients have extensive and diffusely diseased blood vessels. The vessels are also small-sized and therefore it is difficult or even impossible to stent or bypass all of these small vessels.

For patient with refractory angina and PAD, Angiocell® treatment will facilitate the growth of new blood vessel or expansion of existing fine vessel in the heart. This process of angiogenesis by Angiocell® will replenish or restore blood flow to the parts of the heart that is lacking in blood supply. Angiocell® does this effectively because it has been grown in sufficient numbers to cater to the demands of regenerating new blood vessels. By growing the cells ex vivo free from the patient’s exposure to smoking or high blood sugar, these cells are longer-lasting and fully-functional.

Cells identical to Angiocell® have been studied in both patients with angina and patients with heart attack. The overall results after 6-12 months are improvement to patient symptoms, improved exercise capacity and stamina, and reduction of angina. Generally if you continue to suffer with refractory angina and PAD to the point that it is limiting your daily activities, and you have exhausted or are ineligible for current methods of treatment, then you may be eligible for Angiocell® treatment.