The most common risk factors for ulcer formation include diabetic neuropathy, structural foot deformity and peripheral arterial occlusive disease. Diabetic foot ulcers are the most common foot injuries leading to lower extremity amputation. People with diabetes mellitus, a disorder in which blood sugar levels are abnormally high, are at risk for foot ulcers.
The elevated blood sugar levels that occur with diabetes mellitus damage blood vessels, causing them to thicken and leak. Over time, this thickening would disrupt blood supply to the body, especially the skin. Plaque is also more likely to build up in blood vessels (called atherosclerosis), which causes poor circulation. Poor blood supply to the skin often leads to ulcers, especially on the feet, which are slow to heal and often become deep and infected.
6% of diabetic patients develop foot ulcers annually. The incidence of major amputation is between 1-5 cases per 1000 people with diabetes. These are the patients with the most severe ulcers and usually have exhausted all medical and surgical options.
For patient with existing blood vessel blockage, then angioplasty or bypass operation should be considered to restore blood supply. The medicines prescribed by your doctor also help to aid ulcer recovery and clear infection. Any necrotic or gangrenous tissue needs to be debrided back to the healthy area. New methods such as the hyperbaric oxygen therapy may aid recovery of ulcer but do not necessarily treat the underlying blood vessel blockage making recurrence of ulcer very likely. If the bone becomes exposed and infected, then amputation may be necessary.
For patient with diabetic foot ulcer and non-healing wound, DermacellTM treatment will repair damaged blood vessels, regenerates new blood vessels to restore blood supply to your leg and regenerate new skin tissue.
Studies and case reports performed internationally on cells for non-healing ischemic ulcers have been very promising. Patients treated with cells identical to DermacellTM
Generally if you have diabetic foot ulcer or non-healing wound and are ineligible for bypass operation or angioplasty, and contemplated amputation, you may be eligible for DermacellTM treatment.